Polypyridine is a term frequently used in organic chemistry to describe a class of compounds that contain multiple pyridine rings within their molecular structure. Often found in coordination and supramolecular chemistry, polypyridines have a variety of applications in drug development, catalysis, and materials science. However, there are a number of synonymous terms for this compound class, including multi-pyridine ligands, poly(pyridine)s, and multiply substituted pyridines. Each of these terms refers to the same fundamental building blocks, highlighting the versatility and utility of these compounds in numerous scientific fields. Regardless of the terminology used, polypyridines remain a vital component of modern chemistry research, offering fascinating insight into the fundamentals of molecular structure and behavior.